THE MECHANISMS OF INTOXICATIONS

THE EPICHLORHYDRINE BOUNDING BY BLOOD PLASM AND ITS PROTEIN FRACTIONS

I.Yu. Vysotsky, V.D. Lukyanchuk, G.K. Gryzunova

It was founded that the ability of epichlorhydrine (ECH) belayed to the epoxyde joinments’group may take part in the recycled bounding processes with the proteins of the blood plasm and it have only one type of bounding centers on these biological polymeres’ molecule. The main role in ECH bounding either by grade of affinity or by the size of bounding places’ concentration belows to albumine. The calculated association constant and bounding places’ concentration in albumine multi-plicated sum is in 6,7 times higher than one for g-globuline. From the point of view of the occuring of the toxycal features of ECH its bounding by albumine has a positive role in its de-toxycation and excretion of the venue from an organism.

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