IDENTIFICATION OF TETRACONAZOL REPRODUCTION TOXICITY IN WISTAR RATS

N.R. Shepelskaya, S.D. Sapozhnikova

The influence of pesticide tetraconazol upon the reproduction of male and female Wistar rats was studied. Pesticide was administered five days per week for thirteen weeks for males and eleven weeks for females orally by gavage in dose levels 0; 0,2; 0,5; 1,0 mg/kg body weight per day.

Administration of tetraconazol in dosage range of 1,0 mg/kg resulted minimum antiandrogenic effect upon the reproductive capacity of males (decrease in relative testes and epididymis weight, increase of precoital interval).

In addition this dose had adverse effect on the female estrous cycle.

The no-adverse-observable-effect level was considered to be the dose 0,5 mg/kg body weight for both males and females.

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