PROBLEM'S ARTICLES

PRINCIPLES OF CYTOSTATIC-PRODRUGS DESIGN WITH SELECTIVE TOXICITY

N.Ya. Golovenko, I.A. Kravchenko

We analyzed the possibility of making cytostatics on the base of known chemical compounds (nitrogen mustard, 5-fliorouracil, doxorubicin, paclitaxel, etc.) by binding them with natural (peptides) and synthetic high-molecular compounds. The following ways to decrease the cytostatic toxicity were examined: 1) use of the monoclonal antibodies that have a covalent binding with cytostatic drugs or toxins and have high degree of affinity to tumor-associated antigens; 2) imunoliposoms; 3) ADEPT-therapy; 4) immunopolymers

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