DRUG'S TOXICOLOGY

EXPERIMENTAL RESEARCH OF GENERATIVE FUNCTION STATE OF RATS UNDER ESTRAZIN INFLUENCE

L.V. Mogilat

Influence of hormonal antitumor agent estrazin on organism of rats was investigated at entering through a skin and inhalation. Changes of duration and phase structure of estrous cycle, depression of gonadotrophic function of a pituitary gland, decrease of progesterone level, changes of uterus and ovaries morphostructure in female rats and changes of functional state of spermatozoons, decrease of mass quotients of spermaries, seed bubbles and prostates, changes of spermaries histostructure in male rats were observed at entering estrazin through a skin. Single inhalation introduction of estrazin produced reduction of time of spermatozoons motility and decrease of mass quotient of seed bubbles in male rats. Taking into account negative influence of estrazin on generative function at various entering paths in organism, contact working with it in conditions of production is forbidden.

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