DEPENDENCE OF GENOTOXIC EFFECT OF CROTON ALDEHYDE OF ROUTES ADMINISTRATION TO THE ORGANISM

E.A. Bagley, P.G. Zhminko, N.M. Nedopytanskaya, N.O. Kornuta, E.V. Reshavskaya, V.S. Lisovskaya

The genotoxic effect of croton aldehyde was studied in the different organs of Wistar rats after inhalation or oral administration.

The estimation of genotoxic effect was carried out by counting of DNA strand breaks and the transformed cells.

It is established, that equal dozes of croton aldehyde is depending of the route of penetration to the organism of rats and causing different qualitative and quantitative genotoxic effect. After inhalation administration the increase of DNA strand breaks is revealed in a liver — 3,4 times, in a kidneys — 2,2 times, in a lungs — 1,2 times, in a stomach — 1,4 times and a bone marrow — 2,3  times, whereas at oral gavage receipt — in a liver — 1,6 times, in a kidneys — 1,4 times and a bone marrow — 1,5 times.

The most genotoxic effect of croton aldehyde by both routes of penetration to the organism of rats is revealed in a liver. Consequence of this effect became accumulation of DNA damages and their transformation in a liver of rats that was affected by croton aldehyde during 105 weeks. After inhalation administration of croton aldehyde, quantity of the transformed cells in a liver of rats was much more than at oral gavage administration.

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