PROBLEM'S ARTICLES

MOLECULAR EPIDEMIOLOGY: GENE-ENVIRONMENTAL INTERACTIONS, GENOTOXIC CIGARETTE SMOKE PRODUCTS AND HUMAN LANG CANCER RISK

V.N. Zalessky, O.B. Dynnyk, A.A. Filchenkov, L.N. Gusliczer

Summarized in the review are modern ideas about molecular markers of the genetic damage and genotoxic influence of the cigarette smoke products with assessment of molecular epidemiology. Among them are tabacco-associated pyrimidine or purine dimers DNA (DNA adducts) and metabolites, p53 oncoprotein and other biological moleculs — gene-environmental interactions results.

Monitoring of the molecular markers enable to optimize scrining and early diagnosis, therapeutic strategies, prognos of lung cancer.

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