ANTIOXIDANT ACTIVITY AND GENOMOPROTECTIVE ACTION OF PYRIDINE CARBOXYLIC ACIDS PV-20 DERIVATIVE UNDER POISONING WITH TETRACHLOROMETHANE

Yu.I. Gubsky, E.L. Levitsky, A.G. Goryushko, A.N. Marchenko, V.F. Danilenko, T.N. Kurapova, A.N. Velichko, L.P. Babenko

In the conducted studies (in vitro and in vivo) the data indicating utility of research of derivatives of pyridine carboxylic acids (PCA) as potential pharmacological products, which have pronounced antioxidant, hepatoprotective, membranostabilizing, genomoprotective and cytoprotective properties have been received.

It has been established by means of biochemical, physical-chemical and morphological methods that some representatives of these compounds have pronounced antioxidant and antiradical activity. Injection of some PCA derivatives (e.g. PV-20) to the animals, poisoned with tetrachloromethane to a great extent promotes correction of damage of endoplasmic reticulum membranes and fractionated nuclear chromatin of hepatocytes, normalization of their physical-chemical and structural-dynamic characteristics, level of lipids peroxidation and also promotes normalization of liver structural and functional characteristics as the whole organ.

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