PHOSPHORILIC AND TETRAALKYLAMMONIUM DERIVATIVES OF URACIL: SAFETY AND SELECTIVITY OF THEIR MIORELAXANT EFFECTS

V.V. Zobov, K.A. Petrov, A.A. Aslamova, L.A. Beresinsky, V.S. Reznik

Among the new tetraalkylammonium derivatives of 6-methyluracil, that were orientated on "peripheral anionic site" of acethylcholinesterase, the compounds, which can operate a selective miorelaxant effect (till 5 days) on locomotion muscles without breathing oppression, were found (DL₅₀/DE₅₀ till 200,0; mice, i/p); the compounds are classed to "highly/moderately-toxic" (mice) and "practically non-toxic" (daphnia). The oxopyrimidinyl analogues of organophosphorus agents and decamethonium DL₅₀/DE₅₀ doesn't exceed more than 5,0.

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