MECHANISMS OF INTOXICATIONS
PECULIARITIES OF AGE REACTIONS OF PERIPHERAL BLOOD NEUTROFILS OF RATS UPON EXPOSURE TO LOW DOSES OF MERCURY, LEAD AND MANGANESE COMPOUNDS
L.M. Krasnokutska, V.A. Stezhka, L.A. Legkostup, I.M. Andrusyshyna, O.G. Lampeka
Peculiarities of age reactions of peripheral blood neutrofils of rats upon exposure to low doses of mercury, lead and manganese compounds were revealed. It was established that neutrofil leukocytes of young rats are less sensitive towards direct exposure of mercury cations and more sensitive towards direct exposure of lead and manganese cations. Neutrofils of old animals are more sensitive to direct influence on phagocytic activity of mercury and less sensitive to lead and manganese. Neutrofils of both groups are sensitive to decrease of serum opsonizing properties when mercury chloride was administered, which leads to decrease of their absorbent properties. Therefore, revealed misbalances mainly depend on both direct influence of heavy metal cations on cytoplasm membrane, which leads to violation of its specialized function, and indirect changes of activities of humoral factors taking part in phagocytosis regulation, in particular serum opsonizing properties.