COMPARATINE INVESTIGATION OF LEAD AND CADMIUM TOXIC EFFECTS ON RAT SPLEEN AND SPLEEN CELLS

V.A. Stezhka, N.N. Dmytrukha, M.N. Didenko, T.A. Bilko, E.G. Lampeka

It was descavered the distinctions in biological mechanism of lead and cadmium cations action on spleen structure and spleen cells fanctional activity in white rat model intoxication (1/100 LD₅₀). This distinctions were confirmed by direct toxic effects investigation of metal cations on lymphocytes in mixed spleen cell culture in vitro. The both cations had immunotoxic effect on spleen.

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