RESEARCH OF CYCLOPHOSPHANE EFFICIENCY UNDER ACTION OF NEUROPARALYTIC ORGANOPHOSPHORUS COMPOUNDS

P.G. Zhminko, Yu.І. Loboda

It's shown in experiment on the hens, cyclophosphane is effective in the prevention of paresises and paralysises at action neurotoxicants — triorthocresyl phosphate and aphos with hens. The cyclophosphane efficiency consists in an oppression of immunocompetent cell activity and the inhibition of development of autoimmune disorders in the animal organism. The pharmacological effect depends on a doze of neurotoxicant. Cyclophosphane completely prevents development of the delayed neurotoxic effect at aphos action in a dose of 100 mg/kg and in great doses of organophosphorous compounds (aphos — 200 mg/kg, TOCP — 250 mg/kg) cyclophosphane delays appearance and weakens course of patological process. The results of researches can be a basis for development of a treatment way of the delayed neurotoxic at the people.

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