ACTION OF SMALL DOSES OF IONIZING RADIATION ON BLOOD CELLS SURFACE POTENTIAL AGAINST A BACKGROUND ADENYLATE CYCLASE CASCADE MODIFIERS. POSSIBLE TOXICOLOGICAL ASPECTS

V.V. Zhirnov, V.M. Gavij, L.Ye. Kalashnikova

Supplement of radionuclide ⁹⁰Sr (1,2 µCi/l, absorbed dose — 5 µGy) into incubation medium decreases surface potential of human blood erythrocytes and leukocytes on average by 20 and 35 % accordingly. Adenylate cyclase modifiers elevating cAMP level in cell evoke response similar on direction that indirectly indicates inclusion of adenylate cyclase cascade in cell response to ionizing radiation. Findings point out possible cellular mechanism of neurohumoral regulation failure observed at long-term exposure of organism to small doses of ionizing radiation.

article