SUBSTATIONAL OF HEPATOPROTECTIVE ACTION OF BIOMELAN IN EXPERIMENT

G.A. Saifetdinova, A.M. Shayakhmetova, V.M. Kovalenko, O.S. Voloshina, A.K. Voronina

Hepatoprotector efficacy of a new original sorbent biomelan preparation was studied under acetaminophen toxicity using Wistar rats. It was shown preparation administration as treatment or prophylaxis significantly attenuates analgesic toxicity enhancing liver detoxication via concerving both cytochrome P-450 and b₅ content. Biomelan administration prevents electrophylic acetaminophen metabolites binding with the free protein SH-groups, protects enzyme antioxidant catalase activity, corrects lipid turnover as well as limits the phenomenon of hepatocytolysis. Biomelan efficacy prevail over polisorb and metionine. The revealed biomelan hepatoprotector activity makes it possible to be applied as an effective antidote therapy under acetaminophen toxicity.

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