EFFECTS OF SOME DERIVATIVES OF PYRIDINE CARBONIC ACIDS ON STRUCTURAL MODIFICATION OF ISOLATED MEMBRANES OF ENDOPLASMIC RETICULUM OF RAT LIVER AT TETRACHLOROMETHANE INTOXICATION

Yu.I. Gubski, A.G. Goryushko, N.V. Litvinova, R.G. Primak, V.F. Danilenko, N.M. Kurskaya, T.N. Kurapova, A.N. Velichko

Destabilization of membranes of endoplasmic reticulum of rat liver at intoxication with tetrachloromethane (accumulation of LP products, decrease of surface charge, weakening of protein-lipid contact, disturbance of the processes of protein and phospholopid synthesis, etc.) was partially eliminated following intraperitoneal administration of combination of PV-4 and amyzone, which are derivatives of pyridine carbonic acids. The mechanism of correcting the effects of the studied compounds is discussed.

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