WAYS OF CYCLOPHOSPHAMIDE AND IPHOSPHAMIDE BIOTRANSFORMATION. CONNECTION WITH A TOXICITY AND ANTIBLASTOMIC EFFECT

A.A. Pentyuk, A.I. Kakarkin, P.A. Yurchenko, H.V. Tertyshnaya

In the review were considered the pharmakokinetic, the ways of metabolic activation and degradation cyclophosphamide and ifosphamide, and also was given the detailed characteristic of the basic metabolites in view of their toxicity and antiblastomic effect.

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