TREATMENT OF INTOXICATIONS

NEW LINES IN THE DIAGNOSIS OF SECONDARY HEMOCHROMATOSIS RESULTING FROM THE EXCESS INCOME OF IRON INTO THE BODY

O.M. Mykhaylyk, I.P. Lubyanova

The role of nonheme iron species in the pathogenesis of hemochromatosis, feasibilities and restrictions of biochemical and instrumental approaches for the diagnosis of states with body iron overload are considered. The Ukraine possesses scientific and technical potential for the development of new methods for the diagnosis of states with iron overload syndrome. Electron spin resonance technique enables one to quantify concentration of iron in the structure of storage (ferritin/hemosiderin) and transport (transferrin) proteins, degree of transferrin saturation and chelatable iron concentration in the microprobes of the whole blood and blood plasma. The experience of the Ukrainian physicists in the theory of HTS SQUID-probes and development of respective measuring systems ensures design and clinical testing of biosusceptometer for noninvasive measurements of storaged iron concentration in the liver. MRI can be used as a tool for determination of local storaged iron concentration in tissues. Complex approach with account for new indices of iron metabolism, oxygen status, oxidative metabolism indices, usage of modern statistical approaches will assist in revealing peculiarities of the hemochromatosis pathogenesis and contribute into the task of early diagnosis and improved monitoring and treatment of a number of diseases with iron overload syndrome.

article


| contents |