TOXICOLOGY OF PESTICIDES

THE STUDY OF INSECTICIDE KARBOFURAN EFFECT ON GONADAL CAPACITY AND FERTILITY IN WISTAR RATS

N.R. Shepelskaya, L.P. Petrashenko, S.D. Sapognikova

The purpose of this study was to assess in the experiment the influence of pesticide carbofuran upon the gonadal capacity of male and female Wistar rats. Pesticide was administered five days per week for 12-16 weeks for males and 9 weeks for females, orally by gavage in dose levels 0; 0,1; 0,02 mg/kg per day. The NOAEL was considered to be the dose tested — 0,1 mg/kg/day for both males and females.

This results have allowed to place karbofuran into 2 class of hazard for reproduction. This dates were limited for risk assessment and hazard index interpretation for this pesticide.

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