ANTIOXIDATIVE EFFECT OF PYRIDINE CARBONIC ACIDS DERIVATIVES ON RAT BLOOD SERUM AT TETRACHLOROMETHANE INTOXICATION

Yu.I. Gubskiy, E.L. Levitsky, A.G. Goryushko, T.N. Kurapova, V.P. Danilenko, A.N. Marchenko, M.F. Pasechnik

The effects of novel non-steroid anti-inflammatory agents — pyridine carbonic acid derivatives on antioxidative properties of rat blood serum were studied. The novel non-steroid anti-inflammatory agents — amizon and PV-4 appeared to have no effect on free radical generation in vitro. However, the application of amizon and PV-4 at tetrachloromethane intoxication in vivo caused the normalization of blood serum biochemiluminescence induced by hydrogen peroxide. The antioxidative effects of studied agents are discussed.

It is assumed that one of the main antioxidative properties of amizon and PV-4 in vivo is their ability to affect the delivery features of blood serum albumin that lead to increase in both free endogenous steroids and theroxin which are the potent antioxidants.

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