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THE MECHANISMS OF INTOXICATIONS EXPERIMENTAL INVESTIGATION OF HYPOAMMONEMIC ACTIVITY OF L-ARGININE L-GLUTAMATE UNDER SUBACUTE AMMONIUM CHLORIDE INTOXI-CATION Y.V. Merkulova, L.A. Chaika, O.N. Gomon, L.I. Belostotskaya The hypoammonemic activity of L-arginine L-glutamate in compared to activity of individ-ual amino acids mixture (arginine hydrochloride and glutamic acid) has been investigated. It has been established that 5-day long intraperitoneally treatment of L-arginine L-glutamate (400 mg/kg) decreases hyperammonemia, increases ureogenesis, restores acid-base balance. Respective effects of monodrugs of amino acids are certanly lower. Analysis of data obtained allow to conclude that use of L-arginine L-glutamate for treatment hyperammonemia is perspective. |