TREATMENT OF INTOXICATIONS

MECHANISMS OF PROTECTIVE ACTIVITY OF TIN-CONTAINED COMPLEXES OF SYNTHETIC PORPHYRINS BY TOXIC HYPERBILIRUBINEMIA

T.O. Philippova, B.N. Galkin, N.Ya. Golovenko, Z.I. Zhilina, S.V. Vodzinskiy

Tin complexex of meso-substituted synthetic porphyrins of Sn4+-meso-tetraphenylporhyrin (Sn-TPP) and Sn4+-meso-tetrakis(N-methyl-3-pyridyl)porphyrin tetratosylate (Sn TMe-3-PyP) efficiently lowers the serum bilirubin level when administered subcutaneously in a dose of 100 µM/kg body weight to mice. These compounds are active during hyperbilirubinemia, induced by phenylhydrazine, hemin and tetrachlormethane, and also during autoimmune hemolytic anemia. In the latter a drop in serum bilirubin content was observed, as well as a decrease in amount of blood reticulocytes which gives evidence for a milder course of the disease. The Sn complexes under study induce, in vivo, cytochrome P-450, inhibit microsomal heme oxygenase, and lower the intensity of lipid peroxidation. Simultaneously, in vitro the hepatic and splenic heme oxygenase activity is blocked only when a 0,1 µM concentration of Sn-TMe-3-PyP or Sn-protoporphyrin IX is added into incubation mixture. Sn-TPP doesn't have an influence on the activity of this enzyme in vitro.

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