EXPERIMENTAL INVESTIGATION OF LEAD ACETATE AND CADMIUM SULFATE EFFECTS ON RAT ORGANISM NONSPECIFIC RESISTANCE

N.M. Dmytrukha

The state of nonspecific resistance was studied in experimental researches on white rats with isolated and combined intraperitonial injections of lead acetate and cadmium sulfate (doses 1/4, 1/16 and 1/50 LD₅₀). It was established that isolated single injection of 1/4 LD₅₀ lead acetate and cadmium sulfate depressed the cellular and humoral components of nonspecific body defense (absorptive and bactericidal function of neutrophyles, complement titer, levels of immune complexes and opsonin activity in serum). There were observed the inhibition of all phagocitic humoral components after the injection of lead acetate and cadmium sulfate to animals in dose 1/16 LD₅₀. More prolonged exposure of animals (25 injections) to low dose (1/50 LD₅₀) lead and cadmium caused the increase of bactericidal activity of neutrophyles, titer of complement, levels of circulating immune complexes and serum opsonin propety. It was shown that the changes of nonspecific resistance were depended of metals dose and duration of their reception in the animal's organism and carried phase сharacter. The combined injection of two metals strengthened toxic action of one of them. Comparative estimation of immunotoxic effects showed that cadmium had more toxic influence on cellular and humoral components of nonspecific resistance of white rat organism.

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